Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3
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چکیده
منابع مشابه
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues. Different receptors from the OAS family contain one, two, or three copies of the 2-5A ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1419409112